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NSD2 Mouse anti-Human, Clone: CL1057, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524620

Catalog No. PIMA524620


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Description

Description

Immunogen sequence: SANGKTPSCE VNRECSVFLS KAQLSSSLQE GVMQKFNGHD ALPFIPADKL KDLTSRVFNG EPGAHDAKLR FESQEMKGIG TPPNTTPIKN GSPEIKLKIT KTYMNGKPLF ESSICGD Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%. Binds to an epitope located within the peptide sequence RVFNGEPGAHDAKLR as determined by overlapping synthetic peptides.

This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.
Specifications

Specifications

NSD2
Monoclonal
1 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
O96028
MMSET, NSD2, REIIBP, TRX5, WHS, IL5 promoter REII region-binding protein, multiple myeloma SET domain containing protein type III, nuclear SET domain-containing protein 2, probable histone-lysine N-methyltransferase NSD2, trithorax/ash1-related protein 5
Mouse
IgG1
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
7468
Immunohistochemistry
CL1057
Unconjugated
NSD2
Liquid
NSD2
Recombit protein corresponding to Human NSD2
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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