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NSFL1C Rabbit anti-Human, Mouse, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 156201AP

Catalog No. 50-173-0356


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Description

Description

p47, also known as NSFL1C, UBX1, UBXD10 or UBXN2C, is a 370 amino acid protein that localizes to both the nucleus and the golgi apparatus (specifically to golgi stacks) and contains one SEP domain and one UBX domain. Functioning as part of a ternary complex with VCP (a protein involved in the heterotypic fusion of transport vesicles with their target membranes) and Syntaxin 5, p47 interacts with and reduces the ATPase activity of VCP and is required for the fragmentation of golgi stacks during mitosis and for subsequent reassembly of golgi stacks after mitosis. p47 is subject to phosphorylation during mitosis, which inhibits p47-golgi interaction and is, therefore, required for proper golgi stack formation and cisternal regrowth. Human p47 shares 89% sequence identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of p47 exist due to alternative splicing events.
Specifications

Specifications

NSFL1C
0.29 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q9CZ44, Q9UNZ2
NSFL1 (p97) cofactor (p47), NSFL1 cofactor p47, NSFL1C, p47, p97 cofactor p47, UBX1, UBXD10, UBXN2C
Rabbit
IgG
150 μL
-20°C
Primary
386649, 55968
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
NSFL1C
Liquid
Nsfl1c
NSFL1C Fusion Protein Ag8040
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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