NTHL1 Polyclonal Antibody, Invitrogen™

Catalog No.	Quantity
PIPA132336	100 μL

Catalog No. PIPA132336

Supplier: Thermo Scientific PA132336

Description

Rabbit Polyclonal Antibody

PA1-32336 detects NTH from human samples. PA1-32336 has been successfully used in Western blot applications. The PA1-32336 immunogen is: Full-length recombit protein. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Oxygen radicals damage chromosomal DNA causing cell death and inducing mutations. Although a major focus of oxidatively damaged DNA has centered on the repair of 8-oxo-G, a number of other damaged DNA sites are created by free-radical attack on DNA. The human NTH1 repair protein is one enzyme that has been shown to act on a large number of these other oxidatively damaged DNA sites. A homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity. The NTH protein has broad substrate specificity, including numerous ring saturation and fragmentation products of pyrimidines. Research indicates NTH plays a crucial role in removal of oxidative base lesions in mitochondrial DNA.

Specifications

• Antigen: NTHL1
• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NTHL1
• Gene Accession No.: P78549
• Gene Symbols: NTHL1
• Host Species: Rabbit
• Immunogen: Full-length recombit protein.
• Purification Method: Purified
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4913
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG