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Nudel Mouse anti-Canine, Cynomolgus Monkey, Human, Rat, Clone: OTI1G10, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525578

Catalog No. PIMA525578


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Description

Description

Nudel was initially discovered as a protein homologous to Aspergillus NUDE and that associated with Lis1 and polyprotein complex cytoplasmic dynein, both of which have been linked to neuronal development and migration. It was later shown to be a substrate of cdk5, a kinase known to be critical during neuronal migration; phosphorylation of Nudel by cdk5 affects its localization in neurons and affects neuritic morphology. It is thought that together with Lis1, Nudel regulates cytoplasmic dynein, a large polyprotein complex, in neuronal migration and mitosis through direct interactions. Similar interactions are thought to also play a role in membrane traffic in other cells as disruption of Nudel expression through RNA interference perturbed normal endomembrane flux and resulted in the fragmentation of the Golgi apparatus.
Specifications

Specifications

Nudel
Monoclonal
0.32 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9GZM8, Q78PB6, Q4R4S6
NDEL1; nudE nuclear distribution gene E homolog (A. nidulans)-like 1; DKFZp451M0318; EOPA; MITAP1; NUDEL; NUDE-like protein; endooligopeptidase A; mitosin-associated protein MITAP1; nudE nuclear distribution gene E homolog like 1
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
170845, 489495, 721973, 81565
Flow Cytometry, Western Blot
OTI1G10
Unconjugated
NDEL1
Liquid
NDEL1
Full length human recombit protein of NDEL1 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Canine, Cynomolgus Monkey, Human, Rat
Documents
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