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NUMB Rabbit anti-Human, Mouse, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 187011AP

Catalog No. 50-173-2197


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Description

Description

Four transcript variants encoding different isoforms have been found for this gene. The antibody can bind to all these four isoforms P65, P66, P71, and P72, but can not recognize NUMBL.

Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.
Specifications

Specifications

NUMB
0.3 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P49757, Q9QZS3
h Numb, NUMB, numb homolog (Drosophila), Protein numb homolog, Protein S171, S171
Rabbit
IgG
150 μL
-20°C
Primary
18222, 8650
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
NUMB
Liquid
Numb
Peptide
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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