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Tocris™ NVP ADW 742

ATP-competitive inhibitor of IGF1R

Manufacturer:  Tocris™ 5247/10

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Catalog No. 52-471-0


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Disclaimers:

For Research Use Only


Specifications

Description

ATP-competitive inhibitor of IGF1R (IC50 in the range of 0.1-0.2µM). Also inhibits c-Kit kinase activity (IC50 in the range of 3-5µM). Exhibits a synergistic effect with Imatinib, enhancing the sensitivity of multiple small cell lung cancer cell lines to the chemotherapeutics etoposide (Cat. No. 1226) and carboplatin (Cat. No. 2626).
  • Chemical Name: 5-[3-(Phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • Formula: C28H31N5O
  • CAS Number: 475488-23-4
  • Solubility: Soluble to 50mM in DMSO and to 10mM in ethanol
  • Purity: >99
Description & Specifications

Specifications

NVP ADW 742
>99
10mg
NVP ADW 742
453.58
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