OCRL Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 176951AP
This antibody is specific to OCRL.The inositol polyphosphate 5-phosphatases selectively remove the phosphate from the 5-position of various phosphatidylinositols, which generate second messengers in response to extracellular signals. OCRL1 is a type II 5-phosphatase that is mutated in the oculocerebrorenal syndrome of Lowe (OCRL). OCRL is a rare X-linked disorder that is characterized in part by congenital cataracts, mental retardation, muscular hypotonia and renal tubular dysfunction.OCRL1 has a high affinity for phosphatidylinositol 4,5-bisphosphate as well as inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate as substrates. OCRL1 is localized to the Golgi complex and is thought to be part of the trans-Golgi network (TGN), which suggests that OCRL1 plays a role in protein sorting and trafficking within the cell.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|D3ZGS3, Q01968, Q6NVF0|
|INPP5F, LOCR, OCRL, OCRL1|
|317576, 320634, 4952|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|OCRL Fusion Protein Ag11900|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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