OCT2 Mouse anti-Human, Clone: OCT2/2136, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP275733
DescriptionOCT2 Monoclonal antibody specifically detects OCT2 in Human samples. It is validated for Immunohistochemistry (Paraffin).
|10 mM PBS with No Preservative|
|Recombinant fragment of human OCT2 protein (around aa 112-297) (exact sequence is proprietary)|
|Store at 4°C.|
|OCT2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. OCT2 expression can be used as a marker of B-cell lineage and differentiation. Germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells show high level expression of OCT2. Additionally, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, Hodgkin lymphoma display increased expression of OCT2. Several studies of OCT2 expression have shown a low level expression in pre-B, T-cell, myelomonocytic, and epithelial cell lines, whereas all mature B-cell lines have high levels of expression. In spite of scanty evidence for OCT2 expression in T cells, it is believed that this factor participates in transcriptional regulation during T-cell activation.|
|Immunohistochemistry-Paraffin 1-2 ug/ml|
|homeobox protein, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, OCT2Oct-2, Octamer-binding protein 2, Octamer-binding transcription factor 2, OTF-2, OTF2POU domain class 2, transcription factor 2, POU class 2 homeobox 2, POU domain, class 2, transcription factor 2|
|Protein A or G purified|
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