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OCT2 Mouse anti-Human, Clone: OCT2/2136, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP275733

Catalog No. NBP275733


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Description

Description

OCT2 Monoclonal antibody specifically detects OCT2 in Human samples. It is validated for Immunohistochemistry (Paraffin).
Specifications

Specifications

OCT2
OCT2/2136
Unconjugated
10 mM PBS with No Preservative
Purified
POU2F2
Recombinant fragment of human OCT2 protein (around aa 112-297) (exact sequence is proprietary)
60 kDa
100 μg
Store at 4°C.
Monoclonal
OCT2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. OCT2 expression can be used as a marker of B-cell lineage and differentiation. Germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells show high level expression of OCT2. Additionally, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, Hodgkin lymphoma display increased expression of OCT2. Several studies of OCT2 expression have shown a low level expression in pre-B, T-cell, myelomonocytic, and epithelial cell lines, whereas all mature B-cell lines have high levels of expression. In spite of scanty evidence for OCT2 expression in T cells, it is believed that this factor participates in transcriptional regulation during T-cell activation.
Immunohistochemistry (Paraffin)
0.2 mg/ml
Immunohistochemistry-Paraffin 1-2 ug/ml
P09086
homeobox protein, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, OCT2Oct-2, Octamer-binding protein 2, Octamer-binding transcription factor 2, OTF-2, OTF2POU domain class 2, transcription factor 2, POU class 2 homeobox 2, POU domain, class 2, transcription factor 2
Mouse
IgG1 Kappa
Protein A or G purified
Cancer
Primary
5452.0
Human
SDS
Documents
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