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OCTN2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 163311AP

Catalog No. 50-173-0876


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Description

Description

Carnitine (b-hydroxy-g-trimethylaminobutyrate) is a small, highly polar compound that aids in the b-oxidation of long-chain fatty acids. Organic cation/carnitine transporters (OCTN) assist in the elimination of cationic compounds, including xenobiotics, and transport carnitine for reabsorption in the kidney. Similar to organic cation transporters (OCT), OCTN proteins localize to the plasma membrane of epithelial cells. OCTN1 is expressed in kidney, trachea, bone marrow and fetal liver. OCTN2 is abundantly expressed in kidney, skeletal muscle, placenta and heart. OCTN3 is strongly expressed in testis and weakly expressed in kidney. The gene encoding human OCTN1 maps to chromosome 5 and the gene encoding human OCTN2 maps to chromosome 5q31. Mutations in the gene encoding OCTN2 leads to systemic carnitine deficiency (SCD), an autosomal recessive disorder characterized by cardiomyopathy, skeletal myopathy, lethargy, hypoglycemia and hyperammonemia.
Specifications

Specifications

OCTN2
0.19 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O70594, O76082, Q9Z0E8
CDSP, OCTN2, OCTN2VT, SLC22A5
Rabbit
IgG
150 μL
-20°C
Primary
20520, 29726, 6584
Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
SLC22A5
Liquid
SLC22A5
OCTN2 Fusion Protein Ag9450
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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