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OGG1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 151251AP

Catalog No. 50-173-0001


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Description

Description

This antibody has been cited in more than 4 publications, WB and IHC detection in mouse and human.

8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. Coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have a functional yeast (yOgg1) and human (hOgg1) homologue. hOgg1 proteins efficiently released the 8-hydroxyguanine opposite the pyrimidine from DNA and cleaved the AP site in a manner similar to bacterial and yeast enzymes. Genetic backgrounds in control of the repair of damaged DNA are involved in the susceptibility to cancer development. The hOgg1 gene has been mapped to region 3p26.2, a region showing loss of heterozygosity (LOH) in a variety of cancers. In particular, 3p25-p26 is a common LOH region in lung cancer.
Specifications

Specifications

OGG1
0.19 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O08760, O15527, O70249
8 oxoguanine DNA glycosylase, AP lyase, HMMH, HOGG1, MMH, MUTM, OGG1, OGH1
Rabbit
IgG
150 μL
-20°C
Primary
18294, 4968, 81528
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
OGG1
Liquid
Ogg1
OGG1 Fusion Protein Ag7204
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Documents
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