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Alfa Aesar™ Okadaic acid, 98%

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Quantity:
50μg
100μg
300μg
78111-17-8
C44H68O13
805.015
MFCD00083455
QNDVLZJODHBUFM-ZJOMISMMSA-N
okadaic acid
131839562
(2R)-3-[(2S,6R,8S,11R)-2-[(E)-4-[(2R,4R,4aS,6R,8aR)-4-hydroxy-2-[(1S,3S)-1-hydroxy-3-[(2R,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-11-hydroxy-4-
CC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)O)O)O)C)O)O
78111-17-8
C44H68O13
805.015
MFCD00083455
QNDVLZJODHBUFM-ZJOMISMMSA-N
okadaic acid
131839562
(2R)-3-[(2S,6R,8S,11R)-2-[(E)-4-[(2R,4R,4aS,6R,8aR)-4-hydroxy-2-[(1S,3S)-1-hydroxy-3-[(2R,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-11-hydroxy-4-
CC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)O)O)O)C)O)O
Applications
Okadaic acid, is used as an activator of PKC and inhibitor of PP1 and PP2A phosphatases. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. It mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. It is shown to activate atypical protein kinase C in adipocytes.

Solubility
It is soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), methanol (≥1 mg/ml), chloroform, acetone, ethyl acetate, DMF, and dimethylsulfoxide. Insoluble in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away fom strong oxidizing agents.
Quantity 50μg
Color White
UN Number UN3462
Merck Index 14,6819
Formula Weight 805.02
Physical Form Powder
Percent Purity 98%
Chemical Name or Material Okadaic acid

GHS H Statement
H300-H310-H330-H315
Fatal if swallowed.
Fatal in contact with skin.
Fatal if inhaled.
Causes skin irritation.

GHS P Statement
P260-P301+P310-P304+P340-P320-P330-P361-P405-P501a
Do not breathe dust/fume/gas/mist/vapors/spray.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
Specific treatment is urgent (see label).
Rinse mouth.
Remove/Take off immediately all contaminated clothing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

Danger

DOTInformation : Transport Hazard Class: 6.1; Packaging Group: I; Proper Shipping Name: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S.

RTECSNumber : AA8227800

storageNote1 : -30° to -10°C