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Tocris™ OLT 1177

NLRP3 inflammasome inhibitor; disrupts inflammasome formation

Manufacturer:  Tocris™ 6902/10

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Catalog No. 69-021-0


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Description

Description

Dapansutrile is a NLRP3 inflammasome inhibitor that disrupts inflammasome formation. Reduces LPS/ATP-induced IL-1β secretion in human and mouse macrophages in vitro, without affecting TNFα levels. Reduces LPS-induced inflammation in vivo. Also reduces joint swelling and markers of inflammation in synovial fluid in a mouse model of acute arthritis. Displays cardioprotective effects in a mouse model of cardiac ischemic reperfusion injury.

OLT1177® is a registered trademark of Olatec Therapeutics LLC in the United States and other countries.

Specifications

Specifications

133.17
NLRP3 inflammasome inhibitor; disrupts inflammasome formation
10 mg
C4H7NO2S
98%
Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

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