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  7. Ondansetron hydrochloride, Tocris Bioscience™

Ondansetron hydrochloride, Tocris Bioscience™

Catalog Number 289150
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
99614-01-4
C18H20ClN3O
329.83
MFCD00764297,MFCD00374371,MFCD00764297 (anhy.),MFCD00833882
MKBLHFILKIKSQM-UHFFFAOYNA-N
hydrogen ondansetron chloride
2828191
hydrogen 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-2,3,4,9-tetrahydro-1H-carbazol-4-one chloride
[H+].[Cl-].CN1C2=C(C3=CC=CC=C13)C(=O)C(CN1C=CN=C1C)CC2
This item is not returnable. View return policy
99614-01-4
C18H20ClN3O
329.83
MFCD00764297,MFCD00374371,MFCD00764297 (anhy.),MFCD00833882
MKBLHFILKIKSQM-UHFFFAOYNA-N
hydrogen ondansetron chloride
2828191
hydrogen 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-2,3,4,9-tetrahydro-1H-carbazol-4-one chloride
[H+].[Cl-].CN1C2=C(C3=CC=CC=C13)C(=O)C(CN1C=CN=C1C)CC2

Description

Selective 5-HT3 antagonist

Ondansetron hydrochloride is a selective 5-HT3 receptor antagonist (Ki = 6.16 nM). Also an inhibitor of human multidrug and toxin extrusion (MATE) transporter 1 (IC50 = <10-160 nM). Ondansetron blocks 5-HT-evoked transient inward currents (IC50 = 0.1 nM) in human recombinant h5-HT3A receptors. In an animal model of Parkinson's disease, Ondansetron reduces both the severity of dyskinesia and psychosis-like behaviors. Antiemetic; prevents emesis induced by cytotoxic drugs and radiation.
Quantity 50 mg
Formula Weight 329.83
Percent Purity >99%
Chemical Name or Material Ondansetron hydrochloride

Safety and Handling

Recommended Storage Store at Room Temperature
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