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Tocris Bioscience™ ONO AE3 208
High affinity and selective EP4 antagonist
Supplier: Tocris Bioscience™ 3565/10
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Description
ONO AE3 208 is a high affinity and selective EP4 receptor antagonist (Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively). Displays no affinity for EP1, EP2, DP or IP receptors (Ki >10 μM). Inhibits PGE2-induced IL-8 production in colonic epithelial caco-2 cells and attenuates PGE2 inhibition of natural killer T cell activation. Suppresses recovery from experimentally-induced colitis and stimulates CD4+ T cell proliferation in C57BL/6 mice. Also reduces metastasis of mammary tumor cells in a murine model of breast cancer. Orally active.Specifications
| >98% | |
| ONO AE3 208 | |
| ONO AE3 208 |
| 10 mg | |
| 404.43 |
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