OPA1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA116991

Catalog No. 01-670-144

Description

This antibody shares 100% sequence homology with primate, 94% with zebrafish. Suggested positive control: human brain protein.

OPA1 is a dynamin-related GTPase that is critical for the maintenance of mitochondrial morphology and mtDNA. The most commonly associated phenotype with OPA1 mutations is heterozygous optic atrophy, a heterozygous dominant trait that causes reduced visual clarity and sometimes blindness. The disease usually begins in childhood and increases in severity throughout the life of affected individuals. Usually, this phenotype is attributed to the degeneration of optic nerve fibers. Interestingly, the same type of nerve degeneration seems to be partially causative of certain schizophrenia characteristics. OPA1 dysfunction also seems to be implicated in this case; mitochondrial networks associated with critical nerves seem to link schizophrenia and OPA1. The dysfunction is associated with issues with apoptosis and normal cellular metabolic regulation, all regulated through OPA1.

Specifications

• Antigen: OPA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: OPA1
• Gene Alias: 1200011N24Rik; AI225888; AI847218; BERHS; Dynamin-like 120 kDa protein, form S1; Dynamin-like 120 kDa protein, mitochondrial; dynamin-like guanosine triphosphatase; EMBL:AAI11072.1}; hypothetical protein; KIAA0567; Large GTP-binding protein; largeG; lilr3; MGM1; mitochondrial dynamin-like GTPase; mitochondrial OPA1; mKIAA0567; MTDPS14; NPG; NTG; OPA1; opa1 {ECO:0000312; OPA1 mitochondrial dynamin like GTPase; OPA1, mitochondrial dynamin like GTPase; optic atrophy 1; optic atrophy 1 (autosomal dominant); optic atrophy 1 homolog; optic atrophy 1-like protein; optic atrophy protein 1; Optic atrophy protein 1 homolog; RCJMB04_1m16; RN protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100522705, 171116, 424900, 492332, 4976, 74143
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: O60313, P58281, Q2TA68, Q5F499, Q5U3A7
• Gene Symbols: OPA1
• Immunogen: Synthetic peptide corresponding to residues 500-600 of human Opa1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Chicken, Human, Mouse, Pig, Rat, Zebrafish
• Product Type: Antibody
• Isotype: IgG