Tocris Bioscience™ OptoBI-1
Photoswitchable TRPC3/6/7 agonist
Manufacturer: Tocris Bioscience™ 7013/10
DescriptionOptoBI-1 is a photoswitchable TRPC3/6/7 agonist (EC50 for active cis-form ∽0.1 μM at TRPC3). Switches conformation from trans to cis at 365 nm and cis to trans at 430 nm. Returns to trans conformation in the dark after ∽ 50 minutes. No effect observed on TRPC4 or 5. Rapidly changes TRPC3 conductance and inhibits neuronal firing in cis-state.
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