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ORC1 Mouse anti-Human, Clone: ORC1 7F6/1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524770

Catalog No. PIMA524770


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Description

Description

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing.
Specifications

Specifications

ORC1
Monoclonal
1 mg/mL
PBS with 0.02% sodium azide; pH 7.4
Q13415
HS, HSORC1, ORC1, Lorigin recognition complex subunit 1, origin recognition complex, subunit 1, origin recognition complex, subunit 1 (yeast homolog)-like, origin recognition complex, subunit 1 homolog, origin recognition complex, subunit 1 homolog (S. cerevisiae), origin recognition complex, subunit 1-like, origin recognition complex, subunit 1-like (yeast), PARC1origin recognition complex 1, Replication control protein 1
Mouse
IgG1
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
4998
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
ORC1 7F6/1
Unconjugated
ORC1
Liquid
ORC1
Bacterially expressed Human ORC1.
Protein A/G
RUO
Antibody
Monoclonal
Human
Documents
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