Alfa Aesar™ Orotic acid, anhydrous, 97%

Manufacturer: Alfa Aesar™ B25349-36

Quantity 500g

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Catalog No. AAB2534936

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    Chemical Identifiers

    CAS 65-86-1
    Molecular Formula C5H4N2O4
    Formula Weight 156.10g/mol
    MDL Number MFCD00006027
    Synonym 1,2,3,6-Tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid; Uracil-4-carboxylic acid
    Chemical Name or Material Orotic acid, anhydrous

    Specifications

    Melting Point 344° to 347°C
    Quantity 500g
    CAS 65-86-1
    Molecular Formula C5H4N2O4
    Formula Weight 156.10g/mol
    MDL Number MFCD00006027
    Synonym 1,2,3,6-Tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid; Uracil-4-carboxylic acid
    Health Hazard 1 Warning
    Health Hazard 2 GHS H Statement
    H302-H315-H319
    Harmful if swallowed.
    Causes skin irritation.
    Causes serious eye irritation.
    Health Hazard 3 GHS P Statement
    P280-P305+P351+P338-P362-P301+P312-P321-P501a
    Wear protective gloves/protective clothing/eye protection/face protection.
    IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
    Take off contaminated clothing and wash before reuse.
    IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
    Specific treatment (see label).
    Dispose of contents/container in accordance with local/regional/national/international regulations.
    RTECS Number RM3180000
    TSCA TSCA
    Chemical Name or Material Orotic acid, anhydrous
    Assay 97%

    Description

    Applications
    Orotic acid is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5 ft.-phospho-α-d-ribose 1 ft.-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5 ft.-monophosphate (OMP). It is used as a starting material for the potential commercial bioproduction of uridine 5 ft.-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. It may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.

    Solubility
    Slightly soluble in water.

    Notes
    Stable under recommended storage conditions. Incompatible with oxidizing agents.

    GHS H Statement
    H302-H315-H319
    Harmful if swallowed.
    Causes skin irritation.
    Causes serious eye irritation.

    GHS P Statement
    P280-P305+P351+P338-P362-P301+P312-P321-P501a
    Wear protective gloves/protective clothing/eye protection/face protection.
    IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
    Take off contaminated clothing and wash before reuse.
    IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
    Specific treatment (see label).
    Dispose of contents/container in accordance with local/regional/national/international regulations.

    Warning

    SDS & Safety Documents

  • Description & Specifications
  • Safety and Handling

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