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Alfa Aesar™ Orotic acid, anhydrous, 97%

Manufacturer:  Alfa Aesar™ B2534936

Quantity 500g

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Catalog No. AAB2534936


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Specifications

Description

Applications
Orotic acid is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5 ft.-phospho-α-d-ribose 1 ft.-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5 ft.-monophosphate (OMP). It is used as a starting material for the potential commercial bioproduction of uridine 5 ft.-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. It may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.

Solubility
Slightly soluble in water.

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
Description & Specifications

Chemical Identifiers

65-86-1
156.1
1,2,3,6-Tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid; Uracil-4-carboxylic acid
C5H4N2O4
MFCD00006027
Orotic acid, anhydrous

Specifications

65-86-1
156.1
1,2,3,6-Tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid; Uracil-4-carboxylic acid
500g
97%
C5H4N2O4
MFCD00006027
344° to 347°C
Orotic acid, anhydrous

Safety and Handling

SDS & Safety Documents

GHS H Statement
H302-H315-H319
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.

GHS P Statement
P280-P305+P351+P338-P362-P301+P312-P321-P501a
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Take off contaminated clothing and wash before reuse.
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
Specific treatment (see label).
Dispose of contents/container in accordance with local/regional/national/international regulations.

Warning

RTECSNumber : RM3180000

TSCA : TSCA

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