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  7. Orotic acid, anhydrous, 97%, Thermo Scientific Chemicals

Orotic acid, anhydrous, 97%, Thermo Scientific Chemicals

Catalog Number p-7028184
Click to view available options
Quantity:
100 g
500 g
65-86-1
C5H4N2O4
156.097
MFCD00006027
PXQPEWDEAKTCGB-UHFFFAOYSA-N
orotic acid, 6-carboxyuracil, orodin, oropur, orotonin, orotonsan, oroturic, orotyl, vitamin b13, whey factor
967
CHEBI:16742
2,4-dioxo-1H-pyrimidine-6-carboxylic acid
C1=C(NC(=O)NC1=O)C(=O)O
65-86-1
C5H4N2O4
156.097
MFCD00006027
PXQPEWDEAKTCGB-UHFFFAOYSA-N
orotic acid, 6-carboxyuracil, orodin, oropur, orotonin, orotonsan, oroturic, orotyl, vitamin b13, whey factor
967
CHEBI:16742
2,4-dioxo-1H-pyrimidine-6-carboxylic acid
C1=C(NC(=O)NC1=O)C(=O)O

Description

Orotic acid is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5?-phospho-α-d-ribose 1?-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5?-monophosphate (OMP). It is used as a starting material for the potential commercial bioproduction of uridine 5?-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. It may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Orotic acid is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5′-monophosphate (OMP). It is used as a starting material for the potential commercial bioproduction of uridine 5′-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. It may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.

Solubility
Slightly soluble in water.

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
TRUSTED_SUSTAINABILITY
Melting Point 344°C to 347°C
Quantity 100 g
Solubility Information Slightly soluble in water.
Formula Weight 156.1
Percent Purity 97%
Chemical Name or Material Orotic acid, anhydrous

Safety and Handling

Hazard Category H302-H315-H319-H335
Hazard Statement GHS H Statement
H302-H315-H319
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
Precautionary Statement P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
EINECSNumber 200-619-8
RTECSNumber RM3180000
TSCA Yes
Recommended Storage Ambient temperatures
SDS

RUO – Research Use Only

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