OTUD7B Mouse anti-Human, Clone: OTI2E2, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF809496
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCONegative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ft.Lys-48 ft.-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward ft.Lys-11 ft., ft.Lys-48 ft. or ft.Lys-63 ft.- linked polyubiquitin chains. In vitro, has preference for ft.Lys- 11 ft.-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.
|Human recombit protein fragment corresponding to amino acids 449-729 of human OTUD7B produced in E.coli.|
|PBS with 8% trehalose and no preservative; pH 7.3|
|-20° C, Avoid Freeze/Thaw Cycles|
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