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OTUD7B Mouse anti-Human, Clone: OTI2E2, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF809496

Catalog No. 50-166-9538


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates  ft.Lys-48 ft.-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward  ft.Lys-11 ft.,  ft.Lys-48 ft. or  ft.Lys-63 ft.- linked polyubiquitin chains. In vitro, has preference for  ft.Lys- 11 ft.-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.
Specifications

Specifications

OTUD7B
Monoclonal
Unconjugated
OTUD7B
Lyophilized
OTUD7B
Human recombit protein fragment corresponding to amino acids 449-729 of human OTUD7B produced in E.coli.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Western Blot
OTI2E2
PBS with 8% trehalose and no preservative; pH 7.3
Q6GQQ9
CEZANNE, ZA20D1
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
56957
SDS
Documents
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