Selective inhibitor of the first bromodomain of BRD4 (BRD4(1)) (IC50 = 382nM). Exhibits 2-3-fold selectivity for BRD4(1) over the CBP bromodomain and has little affinity for a range of other bromodomains. Reduces viability of lung adenocarcinoma cell lines and attenuates proliferation of MV-4-11 leukemia cells. Cell permeable.
Chemical Name: 3-(3,5-Dimethyl-4-isoxazolyl)-5-hydroxy-α-phenylbenzenemethanol
CAS Number: 1429129-68-9
Solubility: Soluble to 100mM in DMSO and to 10mM in ethanol with gentle warming
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