Invitrogen™ P-cadherin Monoclonal Antibody (12H6)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ 324000

Catalog No. 32-400-0

Description

32-4000 has successfully been used in western blot to detect P-cadherin in MDCK cell lysates.

P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.

Specifications

• Antigen: P-cadherin
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene Accession No.: P22223
• Gene Symbols: Cdh3
• Immunogen: Human P-Cadherin fusion protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Canine
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Frozen), Western Blot
• Clone: 12H6
• Conjugate: Unconjugated
• Gene: Cdh3
• Gene Alias: AI385538; CADH3; cadherin 15, M-cadherin (myotubule); cadherin 3; cadherin 3, type 1, P-cadherin (placental); cadherin-3; Cadp; calcium-dependent adhesion protein, placental; CDH3; CDHP; HJMD; PCAD; P-cadherin; Placental cadherin; Placental-cadherin; RPE-specific cadherin
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1001, 611010
• Content And Storage: -20°C
• Form: Liquid