p170/p-Glycoprotein/MDR Ab-2 Mouse Monoclonal Antibody, Epredia™

Ensure accurate, reproducible results with the Epredia™ p170/p-Glycoprotein/MDR Ab-2, Mouse Monoclonal Antibody.

Supplier:  Epredia MS660P

Catalog No. MS660P

Description

Multi-drug resistance(MDR) associated p-glycoprotein (p170) causes resistance to various drugs in a number of cancer patients. It exists in a soluble and membrane associated form. Soluble P-glycoprotein is detected in extracellular fluids of cancer patients, such as malignant ascites and serum. The Mr of soluble P-glycoprotein is the same as that of membrane bound P-glycoprotein.

Host Species: Mouse

Clone: F4

Isotype: IgG1

Species Reactivity: Human, Chinese Hamster. Does not react with mouse. Others not known.

Epitope: Extracellular amino terminal half. This epitope is resistant to formalin fixation and periodate oxidation and is different from those of other commonly known MAbs to p-glycoprotein, such as C219, JSB-1, and MRK16, which recognize an intracellular and extracellular epitope of p-glycoprotein, respectively.

Immunogen: Human and hamster drug-resistant viable cells followed by crude plasma membranes

Molecular Weight: 170kDa

Positive Control: Drug-resistant cells, Kidney or breast CA

Cellular Localization: Membrane

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting
• Immunofluorescence
• Flow Cytometry (Fixed cells only)

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: p170/p-Glycoprotein/MDR Ab-2
• Classification: Monoclonal
• Concentration: 200μg/mL
• Host Species: Mouse
• Quantity: 1 mL
• Research Discipline: Cancer and Tumor Biology
• Target Species: Hamster, Human
• Isotype: IgG1

• Applications: Immunofluorescence, Western Blot
• Clone: F4
• Conjugate: Unconjugated
• Immunogen: Human and hamster drug-resistant viable cells followed by crude plasma membranes
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Concentrated