Thermo Scientific Lab Vision p53, Rabbit Monoclonal Antibody (Clone Y5)
Employ part of a comprehensive antibody portfolio with the Thermo Scientific p53, Rabbit Monoclonal Antibody (Clone Y5).
Manufacturer: Thermo Scientific RM2103S
Employ part of a comprehensive antibody portfolio with the Thermo Scientific p53, Rabbit Monoclonal Antibody (Clone Y5). Studies show rabbit monoclonal antibodies are more sensitive and specific than other available markers.p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein. p53 senses DNA damage and possibly facilitaes repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma. p53 is detected by immunostains only if the mutation causes protein stability (although protein may be nonfunctional) or a physiologic response. The physiologic response may be due to genetic changes induced by cellular stress from anoxia or aneuploidy; or genetic damage to other pathways controlling p53 such as MDM2 or alternative reading frame.
Host Species: Rabbit
Species Reactivity: Human.Others not known.
Immunogen: A synthetic peptide derived from N- terminal residues of human p53
Molecular Weight: 53kDa
Positive Control: Colon or Breast CA
Cellular Localization: Nuclear
- Immunohistochemistry (Formalin/paraffin)
|A synthetic peptide derived from N- terminal residues of human p53|
|Culture Supernatant with Azide|
|Cancer and Tumor Biology|
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