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Thermo Scientific™ Lab Vision™ p57 Kip2 Ab-3, Mouse Monoclonal Antibody

Deliver accurate, reproducible results with the Thermo Scientific™ p57Kip2 Ab-3, Mouse Monoclonal Antibody.

Specifications

Antigen p57superscriptKip2superscript
Clone KP39
Applications Immunohistochemistry (Paraffin), Immunoprecipitation
Classification Monoclonal
Host Species Murine
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Products 2
Catalog Number Mfr. No. Concentration Format Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Concentration Format Quantity Price Quantity & Availability  
MS897P0
View Documents
Thermo Scientific™
MS897P0
200μg/mL Concentrated; Purified with BSA and azide 100μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
MS897P
View Documents
Thermo Scientific™
MS897P
200μg/mL Concentrated; Purified with BSA and azide 1mL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
Description

Description

Deliver accurate, reproducible results with the Thermo Scientific™ p57Kip2 Ab-3, Mouse Monoclonal Antibody.

p57Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms.

Host Species: Mouse

Clone: KP39

Isotype: IgG2b/κ

Species Reactivity: Human and Mouse. Others not known.

Epitope: Not determined

Immunogen: Recombinant human p57Kip2 protein

Molecular Weight: 57kDa

Positive Control: LS174T cells, Colon CA or placenta

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting (Not suitable)
  • Immunoprecipitation (Native verified)

Specifications

Specifications

p57superscriptKip2superscript
Immunohistochemistry (Paraffin), Immunoprecipitation
Murine
Cell Cycle
Recombinant human p57superscriptKip2superscript protein
KP39
Monoclonal
IVD
Primary
IgG2b kappa
SDS
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