Invitrogen™ SESN1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5101880

Catalog No. PIPA5101880

Description

Antibody detects endogenous levels of total SESN1.

This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Specifications

• Antigen: SESN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Sesn1
• Gene Alias: 1110002G11Rik; AU044290; LOW QUALITY PROTEIN: sestrin-1; p53 activated gene 26; p53 regulated PA26 nuclear protein; p53-regulated protein PA26; PA26; Sesn1; Sest1; sestrin 1; sestrin-1; si:ch211-51a19.4; WITHDRAWN: zgc:103669; zgc:103669; zgc:91970
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 140742, 27244, 294518
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P58006, Q9Y6P5
• Gene Symbols: Sesn1
• Immunogen: A synthesized peptide derived from human SESN1(Accession Q9Y6P5), corresponding to amino acid residues R127-L177.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov