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PAG1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 250291AP

Catalog No. 50-173-4681


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Description

Description

PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and thereby activates the protein tyrosine kinase Csk, the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding and increased activation of the protein tyrosine kinase Lck.
Specifications

Specifications

PAG1
0.2 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q3U1F9, Q9NWQ8
CBP, Csk binding protein, PAG, PAG1
Rabbit
IgG
150 μL
-20°C
Primary
55824, 94212
Western Blot
Unconjugated
PAG1
Liquid
PAG1
PAG1 Fusion Protein Ag13393
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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