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PAK4 Mouse anti-Human, Clone: OTI1C7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526859

Catalog No. PIMA526859


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Description

Description

The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK4 was initially identified as a novel effector of Cdc42Hs. Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization, showing that it is involved in cytoskeletal reorganization. Other experiments have shown PAK4 to be essential for embryonic viability and proper neuronal development. PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways.
Specifications

Specifications

PAK4
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O96013
PAK-4; p21(CDKN1A)-activated kinase 4; p21-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; serine/threonine-protein kinase PAK 4
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
10298
Immunohistochemistry (Paraffin), Western Blot
OTI1C7
Unconjugated
PAK4
Liquid
PAK4
Human recombit protein fragment corresponding to amino acids 1-308 of PAK4 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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