Pan SHANK Mouse anti-Human, Mouse, Rat, Clone: S23b-49, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527633
DescriptionShank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina. Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer ft.s disease.
|PBS with 50% glycerol and 0.09% sodium azide; pH 7.4|
|Q9QX74, Q9UPX8, D3YZU1, Q9Y566, Q4ACU6, Q80Z38, Q9BYB0, Q9JLU4, Q9WV48|
|Cortactin binding protein 1, Cortactin SH3 domain-binding protein, Cortactin-binding protein 1, CortBP1, CTTNBP1, GKAP/SAPAP interacting protein, GKAP/SAPAP-interacting protein, KIAA1022, Proline rich synapse associated protein 1, Proline-rich synapse-associated protein 1, ProSAP1, SH3 and multiple ankyrin repeat domains protein 2, SHAN2_RAT, SHANK, Shank2, SPANK-3|
|171093, 210274, 243961, 59312, 50944, 58234, 22941, 78957, 85358|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot|
|Shank1, SHANK2, Shank3|
|Fusion protein amino acids 84-309 of rat Shank2|
|Human, Mouse, Rat|
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