Invitrogen™ PANK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114220

Catalog No. PIPA5114220

Description

Immunogen sequence: ERFGLPGWAV ASSFGNMMSK EKREAVSKED LARATLITIT NNIGSIARMC For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 93%; Rat: 100%; Sheep: 100%; Zebrafish: 86%.

Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA is the major acyl carrier, playing a central role in intermediary and fatty acid metabolism. In both yeast and fly, each with only 1 pantothenate kinase gene, the null mutant is inviable. Mutations in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS). PKAN is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Mutations in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).

Specifications

• Antigen: PANK2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PANK2
• Gene Alias: 4933409I19Rik; AI642621; C20orf48; Hallervorden-Spatz syndrome; HARP; hPanK2; HSS; NBIA1; PANK2; pantothenate kinase 2; pantothenate kinase 2 (Hallervorden-Spatz syndrome); pantothenate kinase 2, mitochondrial; pantothenate kinase 2, mitochondrial isoform 1 preproprotein; pantothenate kinase 2, mitochondrial-like; pantothenic acid kinase 2; PKAN
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 80025
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q9BZ23
• Gene Symbols: PANK2
• Immunogen: Immunogen sequence: ERFGLPGWAV ASSFGNMMSK EKREAVSKED LARATLITIT NNIGSIARMC.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov