PARN Mouse anti-Human, Clone: OTI1G7, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526549
DescriptionThe protein encoded by this gene is a 3 ft.-exoribonuclease, with similarity to the RNase D family of 3 ft.-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|DAN, deadenylating nuclease, deadenylation nuclease, poly(A)-specific ribonuclease (deadenylation nuclease), poly(A)-specific ribonuclease PARN, polyadenylate-specific ribonuclease|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 1-266 of PARN produced in E.coli|
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