Invitrogen™ PARP6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531988

Catalog No. PIPA531988

Description

Recommended positive controls: Jurkat, BCL-1. Predicted reactivity: Mouse (100%), Rat (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.

Specifications

• Antigen: PARP6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Parp6
• Gene Alias: 1700119G14Rik; 2310028P13Rik; 3110038K10Rik; ADP-ribosyltransferase diphtheria toxin-like 17; ARTD17; C030013N01Rik; PARP6; PARP-6; PARP-6-B1; PARP-6-C; pART17; poly (ADP-ribose) polymerase family, member 6; poly [ADP-ribose] polymerase 6; poly(ADP-ribose) polymerase family member 6; Protein mono-ADP-ribosyltransferase PARP6; RGD1310937
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 56965, 67287
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.79 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q2NL67, Q6P6P7
• Gene Symbols: Parp6
• Immunogen: Recombinant fragment corresponding to a region within amino acids 339 and 575 of Human PARP6.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov