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PAX5 Rat anti-Human, Mouse, Clone: 1H9, eBioscience™ Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  LIFE TECHNOLOGIES 14991895

Encompass

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Catalog No. 14-991-895


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Description

Description

The MAb 1H9 recognizes both mouse and human Pax5. Pax5, also known as BSAP (B cell specific activator protein), is a member of the paired box (pax) family of transcription factors. Pax5 is the only member of the pax family of transcription factors that is expressed in hematopoietic cells. During embryogenesis, Pax5 is transiently expressed in the brain of mice and in the mesencephalon and spinal cord of humans. Its expression is upregulated early in B cell development at the time of B cell commitment and is maintained throughout most subsequent stages. Suppression of Pax5 is essential for expression of Blimp-1 and the terminal differentiation of plasma cells. In the spleen, expression of Pax5 is higher in marginal zone B cells (B220+ CD21high CD23low) than in other B cells, especially the transition 1 stage (B220+ CD21- CD23-). In addition to its role in B cell development, Pax5 also affects VH-DJH heavy chain recombination as well as influencing the expression of many other B and non-B cell related proteins. Pax5 expression is correlated with many neoplasms. In diffuse large B cell lymphomas (DLBCL) and non-Hodgkin lymphomas Pax5 is often mutated while in B-cell ALL, expression levels are high. Additionally, translocation with elastin, IGH, ETV6, FOXP1, and EVI3 have been identified. eBioscience recommends that the Foxp3 Buffers (cat. 00-5521) be used for optimal results when using this antibody for intracellular staining and flow cytometric analysis.

PAX5 Monoclonal antibody specifically detects PAX5 in Human, Mouse samples. It is validated for ChIP assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
Specifications

Specifications

PAX5
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q02548, Q02650
Rat
10 mg
Primary
Human, Mouse
Antibody
IgG2a κ
ChIP assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
1H9
Unconjugated
PAX5
ALL3; B-cell lineage specific activator; B-cell-specific transcription factor; BSAP; EBB-1; KLP; paired box 5; paired box gene 5; paired box homeotic gene 5; paired box protein Pax-5; paired domain gene 5; PAX5; Pax-5; Pax5 variant 1; Pax5 variant 2; RGD1565236; transcription factor PAX 5
Affinity chromatography
RUO
18507, 5079
4° C
Liquid
SDS
Documents
Product Certifications
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