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Pax6 Mouse, Clone: PAX6/496, Novus Biologicals™
Mouse Monoclonal Antibody has been used in 1 publication
Supplier: Novus Biologicals NBP2328930.2MG
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DescriptionPax6 Monoclonal antibody specifically detects Antigen in Chicken, Human, Mouse, Rat samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Western Blotting.
|PBS with 0.05% BSA. with 0.05% Sodium Azide|
|keratitis), MGC17209, Oculorhombin, paired box 6, paired box protein Pax-6|
|Cellular Markers, Diabetes Research, Neuronal Stem Cell Markers, Neuroscience, Sensory Systems, Stem Cell Markers, Stem Cells, Transcription Factors and Regulators, Vision|
|Human, Mouse, Rat, Chicken|
|Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence|
|Western Blot 0.5-1ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml|
|Recombinant fragment (N-terminus; aa 1-300) of human PAX6 protein|
|Protein A purified|
|Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.|
|Store at 4C.|
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