PAX6 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA585374

Catalog No. PIPA585374

Description

Keep as concentrated solution. Positive Control: 293T, HeLa, mouse brain, rat brain, PAX6-transfected 293T. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

PAX genes encode nuclear transcription factors which are regarded as major controllers of developmental processes in both vertebrates and invertebrates. Mutations in murine PAX genes underlie three natural mouse alleles and several corresponding human syndromes (aniridia, foveal hypoplasia and Peters′ anomaly). Murine PAX genes have been shown to be proto-oncogenes. Furthermore, human PAX genes have recently been demonstrated to play an influential part in some common human cancers such as brain tumors and lymphomas. All PAX genes encode a DNA-binding domain termed the paired domain and in addition some also encode a second binding domain--the paired type homeobox. PAX6 is involved in the early development of the optical vesicle and has been shown to interact with Six3, another important visual development protein.

Specifications

• Antigen: PAX6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PAX6
• Gene Alias: AN antibody; AN2 antibody; D11S812E antibody; MGC17209 antibody; MGDA antibody; WAGR antibody; PAX6 antibody; paired box protein Pax-6 antibody; aniridia type II protein antibody; oculorhombin antibody; paired box homeotic gene-6 antibody; paired box 6 antibody
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5080, 25509, 18508
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
• Concentration: 1.8 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: P26367, P63015, P63016
• Gene Symbols: Pax6
• Immunogen: Recombit protein encompassing a sequence within the center region of human PAX6.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG