DescriptionThis gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1; 19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
|PBS with 30% glycerol and 0.035% sodium azide; pH 7.5|
|2310056B04Rik; D230003C07Rik; DKFZp686B09108; Homeobox protein PBX1; Homeobox protein PRL; MGC126627; OTTHUMP00000032205; PBX homeobox 1; Pbx1; Pbx-1; pre B cell leukemia homeobox 1; pre-B-cell leukemia homeobox 1; Pre-B-cell leukemia transcription factor 1; PRL|
|ChIP Assay, Immunohistochemistry, Western Blot|
|This PBX1b antibody was raised against a recombinant protein corresponding to amino acids 319 - 347 of human PBX1b.|
|-20°C, Avoid Freeze/Thaw Cycles|
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