PCBP1 Mouse anti-Human, Clone: OTI3D12, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526791
DescriptionThis intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular polydomains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5 ft.-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|PCBP1; poly(rC) binding protein 1; HNRPE1; HNRPX; hnRNP-E1; hnRNP-X; alpha-CP1; heterogeneous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein X; nucleic acid binding protein sub 2.3|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 1-225 of PCBP1 produced in E.coli|
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