PCDHGB2 Mouse anti-Human, Mouse, Clone: S148-30, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527617
DescriptionThis gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.4|
|PCDH-gamma-B2, PCDHGB2, Protocadherin gamma B2, Protocadherin gamma subfamily B, 2, Protocadherin gamma subfamily B2, Gamma Protocadherin-B2, Gamma Protocadherin B2|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|Fusion protein amino acids 719-804 (variable cytoplasmic domain) of mouse Gamma- Protocadherin Gamma B2. Human: 68% identity (60/88 amino acids identical) >60% identity with other Gamma-protocadherin-B proteins|
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