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PCGF1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549390

Catalog No. PA549390


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Description

Description

Predicted to react with bovine based on sequence homology.

Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin- dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down- regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A  ft.Lys-119 ft., rendering chromatin heritably changed in its expressibility.
Specifications

Specifications

PCGF1
Polyclonal
Unconjugated
PCGF1
Liquid
PCGF1
KLH conjugated synthetic peptide between 117-151 amino acids from the Central region of human PCGF1.
Protein A, Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
0.4 mg/mL
PBS with 0.09% sodium azide
Q9BSM1, Q8R023, Q6DLV9
Polycomb group RING finger protein 1, Nervous system Polycomb-1, NSPc1, RING finger protein 68, PCGF1, NSPC1, RNF68
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
312480, 69837, 84759
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