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PCID2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA551182

Catalog No. PA551182


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Description

Description

The antibody detects endogenous levels of total PCID2 protein.

Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.
Specifications

Specifications

PCID2
Polyclonal
Unconjugated
PCID2
Liquid
PCID2
Fusion protein of human PCID2
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
2.4 mg/mL
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Q5JVF3, Q8BFV2
F10
Rabbit
IgG
100 μL
-20°C
Primary
234069, 55795
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