PCMT1 Mouse anti-Human, Clone: OTI4A4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527235
DescriptionThree classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 188.8.131.52) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|PIMT, L-isoaspartyl protein carboxyl methyltransferase, protein L-isoaspartyl/D-aspartyl methyltransferase, protein-L-isoaspartate(D-aspartate) O-methyltransferase, protein-beta-aspartate methyltransferase|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 60-285 of PCMT1 produced in E.coli|
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