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Tocris Bioscience™ PCNA I1

PCNA inhibitor

$149.00 - $629.00


Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
54-191-0 View Documents Tocris Bioscience™
5419/10
Each for $149.00
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54-195-0 View Documents Tocris Bioscience™
5419/50
Each for $629.00
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Description

Description

Proliferating cell nuclear antigen (PCNA) inhibitor. Directly binds PCNA trimers (Kd = 0.41 μM), reduces chromatin-associated PCNA in cells, inhibits cell growth through induction of S and G2M arrest, and attenuates DNA replication in cells. Inhibits growth of a range of tumor cell lines in vitro with IC50 values in the nanomolar to low micromolar range. Inhibits growth of prostate tumor xenografts in mice.

For Research Use Only

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