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Tocris Bioscience PD 180970
p210Bcr/Abl kinase inhibitor; also inhibits c-Src and KIT
Manufacturer: Tocris Bioscience 4965/10
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Description
ATP-competitive inhibitor of p210bcr/abl tyrosine kinase; selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells. Inhibits in vivo tyrosine phosphorylation of Gab2, CrkL and p210bcr/abl (IC50 values are 80, 80 and 170 nM respectively). Potently inhibits p210bcr/abl autophosphorylation in vitro (IC50 = 5 nM). Also potently inhibits c-Src and KIT (IC50 values are 0.8 and 50 nM, respectively).Specifications
PD 180970 | |
>98 | |
10mg |
PD 180970 | |
429.27 |
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Product Title
For Research Use Only