Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Life Sciences
  4. Enzymes and Inhibitors
  5. Custom Enzymes and Inhibitors
  6. 496510R

Tocris Bioscience™ PD 180970

p210Bcr/Abl kinase inhibitor; also inhibits c-Src and KIT

Manufacturer:  Tocris Bioscience™ 4965/10

Catalog No. 49-651-0R


Add to cart
This item is not returnable. View return policy

Description

Description

ATP-competitive inhibitor of p210bcr/abl tyrosine kinase; selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells. Inhibits in vivo tyrosine phosphorylation of Gab2, CrkL and p210bcr/abl (IC50 values are 80, 80 and 170 nM respectively). Potently inhibits p210bcr/abl autophosphorylation in vitro (IC50 = 5 nM). Also potently inhibits c-Src and KIT (IC50 values are 0.8 and 50 nM, respectively).
Specifications

Specifications

PD 180970
>98
10mg
PD 180970
429.27
SDS
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only