PD-L2 (PDCD1LG2) Mouse anti-Human, Clone: OTI12C7, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF808982
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCOCD273 (PDCD1 Ligand 2, Programmed cell death 2 ligand 2, PD-L2, B7-DC) is involved in cell-mediated immune responses initiated by T lymphocytes that are stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as CD273 that mediate inhibitory signals from the APC (antigen presenting cell). CD273 can bind two different but related ligands, PDL-1 and PDL-2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PDL-2 can act to stimulate an immunogenic response through and alternative receptor from PD-1. At least three isoforms of PDL-2 are known to exist; CD273 is specific to the largest isoform. Diseases associated with CD273 include cysticercosis, and myasthenic syndrome.
|Full length human recombit protein of human PDCD1LG2 produced in HEK293T cell.|
|PBS with 8% trehalose and no preservative; pH 7.3|
|B7DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2, bA574F11.2|
|-20° C, Avoid Freeze/Thaw Cycles|
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