PDE8B Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA131144
PA1-31144 detects PDE8B from rat, human, mouse samples. PA1-31144 has been successfully used in Western blot and imunnoprecipitation applications. The PA1-31144 immunogen is: Synthetic peptide (Human). Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the 5-prime,3-prime-cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been grouped into several families based on substrate affinities, inhibitor sensitivities, mode of regulation, and amino acid sequence homologies. The PDE8 family contains high-affinity cAMP-specific, IBMX (3-isobutyl-1-methyl-xanthine)-insensitive PDEs, such as PDE8B. All PDEs share a conserved C-terminal catalytic region and a variable N-terminal domain that presumably accounts for the distinctive regulatory properties unique to the individual families.
|Synthetic peptide (Human).
|Human, Mouse, Rat
|Immunoprecipitation, Western Blot
|Antigen affinity chromatography
|218461, 309962, 8622
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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