PDIR Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 155451AP
DescriptionPDIR (protein disulfide isomerase-related protein) is a novel PDI protein that was originally isolated from a human placental cDNA library. It has been suggested that from its nucleotide sequence, PDIR has three CXXC-like motifs (Cys-Ser-Met-Cys, Cys-Gly-His-Cys and Cys-Pro-His-Cys), which are found in the PDI superfamily of proteins. The CXXC motif is responsible for oxidoreductase activity. PDIR is also shown to have a putative endoplasmic reticulum (ER) retention signal ft.Lys-Glu-Glu-Leu ft. at its carboxyl terminus, indicative of ER resident proteins. Northern blot analysis of PDIR indicates that it is preferentially expressed in cells actively secreting proteins. It has also been shown that expression of PDIR is stress-inducible. Data suggest that PDIR, like other PDIs, has oxidoreductase activity of disulfide bonds and facilitates the protein folding process within the lumen of the ER.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Q14554, Q5I0H9, Q921X9|
|PDIA5, PDIR, Protein disulfide isomerase A5|
|10954, 360722, 72599|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|PDIR Fusion Protein Ag7901|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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