PDK1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 182621AP
This antibody is specific to PDK1.Serine/threonine kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Q15118, Q63065, Q8BFP9|
|PDH kinase 1, PDHK1, PDK1, Pyruvate dehydrogenase kinase isoform 1|
|116551, 228026, 5163|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PDK1 Fusion Protein Ag13121|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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