PDXK Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA593146

Catalog No. PIPA593146

Description

Immunogen sequence: MEEECRVLSI QSHVIRGYVG NRAATFPLQV LGFEIDAVNS VQFSNHTGYA HWKGQVLNSD ELQELYEGLR LNNMNKYDYV LTGYTRDKSF LAMVVDIVQE LKQQNPRLVY VCDPVLGDKW DGEGSMYVPE DLLPVYKEKV VPLADIITPN QFEAELLSGR KIHSQEEALR VMDMLHSMGP DTVVITSSDL PSPQGSNYLI VLGSQRRRNP AGSVVMERIR MDIRKVDAVF VGTGDLFAAM LLAWTHKHPN NLKVACEKTV STLHHVLQRT IQCAKAQAGE GVRPSPMQLE LRMVQSKRDI EDPEIVVQAT VL; Positive Samples: MCF7, HT-29, HeLa, HepG2, Mouse liver, Mouse kidney, Mouse brain, Rat liver; Cellular Location: Cytoplasm

Pyridoxal kinase (PDXK) converts vitamin B6 to pyridoxal-5-phosphate (PLP), an essential cofactor in the intermediate metabolism of amino acids and neurotransmitters. The PDXK gene encodes a 312-amino acid polypeptide, and expression of the cDNA reveals pyridoxal kinase activity. Northern blot analysis revealed that a major 1.5-kb PDXK transcript is expressed in all tissues tested. The expression of PDXK shows circadian oscillations. The expression of Pdxk in mouse liver and brain is regulated by the 3 PAR bZIP transcription factors, Dbp, Hlf, and Tef, which also show circadian oscillations in expression. Mice devoid of all 3 transcription factors show decreased levels of brain PLP, serotonin, and dopamine, and are highly susceptible to frequently lethal generalized spontaneous and audiogenic epilepsies.

Specifications

• Antigen: PDXK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PDXK
• Gene Alias: 2310036D04Rik, AA119688, C21orf124, C21orf97, C77999, epididymis secretory sperm binding protein Li 1a, HEL-S-1a, Pdxk, Pkh, PNK, PRED79, pyridoxal (pyridoxine, vitamin B6) kinase, pyridoxal kinase, pyridoxamine kinase, pyridoxine kinase, vitamin B6 kinase
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 216134, 83578, 8566
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunocytochemistry, Western Blot
• Concentration: 4.95 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
• Gene Accession No.: O00764, O35331, Q8K183
• Gene Symbols: PDXK
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-312 of human PDXK (NP_0036721)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG