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PDXK Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 153091AP

Catalog No. 50-173-0139


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Description

Description

Pyridoxal kinase (PDXK) converts vitamin B6 to pyridoxal-5-phosphate (PLP), an essential cofactor in the intermediate metabolism of amino acids and neurotransmitters. The PDXK gene encodes a 312-amino acid polypeptide, and expression of the cDNA reveals pyridoxal kinase activity. Northern blot analysis revealed that a major 1.5-kb PDXK transcript is expressed in all tissues tested. The expression of PDXK shows circadian oscillations. The expression of Pdxk in mouse liver and brain is regulated by the 3 PAR bZIP transcription factors, Dbp, Hlf, and Tef, which also show circadian oscillations in expression. Mice devoid of all 3 transcription factors show decreased levels of brain PLP, serotonin, and dopamine, and are highly susceptible to frequently lethal generalized spontaneous and audiogenic epilepsies.
Specifications

Specifications

PDXK
0.33 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O00764, O35331, Q8K183
C21orf124, C21orf97, PDXK, PKH, PNK, PRED79, Pyridoxal kinase, Pyridoxine kinase
Rabbit
IgG
150 μL
-20°C
Primary
216134, 83578, 8566
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
PDXK
Liquid
PDXK
PDXK Fusion Protein Ag7451
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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