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PDXK Mouse anti-Human, Clone: OTI3G2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525573

Catalog No. PIMA525573


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Description

Description

Pyridoxal kinase (PDXK) converts vitamin B6 to pyridoxal-5-phosphate (PLP), an essential cofactor in the intermediate metabolism of amino acids and neurotransmitters. The PDXK gene encodes a 312-amino acid polypeptide, and expression of the cDNA reveals pyridoxal kinase activity. Northern blot analysis revealed that a major 1.5-kb PDXK transcript is expressed in all tissues tested. The expression of PDXK shows circadian oscillations. The expression of Pdxk in mouse liver and brain is regulated by the 3 PAR bZIP transcription factors, Dbp, Hlf, and Tef, which also show circadian oscillations in expression. Mice devoid of all 3 transcription factors show decreased levels of brain PLP, serotonin, and dopamine, and are highly susceptible to frequently lethal generalized spontaneous and audiogenic epilepsies.
Specifications

Specifications

PDXK
Monoclonal
0.45 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O00764
Pyridoxal kinase; Pyridoxine kinase; PDXK; PKH; PNK;
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8566
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
OTI3G2
Unconjugated
PDXK
Liquid
PDXK
Full length human recombit protein of PDXK produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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